Freeze drying technology gets a boost via rocket science

first_imgShare Facebook Twitter Google + LinkedIn Pinterest Purdue University has created a new lyophilization consortium, LyoHUB, to improve freeze-drying technology to make food, pharmaceuticals and biotech products safer and more affordable.The center is funded by the National Institute of Standards and Technology through a $453,623 planning grant from its Advanced Manufacturing Technology Consortia, or AMTech, program.Lyophilization, the process by which water is gently removed from materials to make them more stable and lengthen their shelf life, is a high-priority technology challenge, said Elizabeth Topp, head of Purdue’s Department of Industrial and Physical Pharmacy who co-leads the center with Alina Alexeenko, an associate professor of aeronautics and astronautics.“You don’t think of it when enjoying the dried strawberries in your morning cereal, but lyophilization is a $30 billion piece of the U.S. food and pharmaceutical manufacturing industry,” said Topp, who also is the Dane O. Kildsig Chair in Industrial and Physical Pharmacy. “Without this freeze-drying process, important drugs would not be available to those who need them. Many protein-based drugs, certain vaccines, probiotics and the dried fruit used in many products would not be available without it. However, the current lyophilization process hasn’t changed in 50 years, and it is very expensive.About 25% of new injectable drugs, vaccines and biological products are formulated in a lyophilized form, and for many proteins, peptides and vaccines, it is the only way to produce stable, biologically active products with a long shelf-life, Topp said.Stagnation in lyophilization technology could have a negative economic impact, as companies look to offshore manufacturing to reduce costs, Topp said.“If we can reduce the manufacturing costs through technological innovation, we could bring the manufacturing back, which would mean more jobs and benefit to the U.S. economy,” she said. “It is similar to the semiconductor industry a few years ago. Consortia formed to improve the technology that kept U.S. manufacturing competitive and revolutionary advances occurred that led to the ubiquitous smart devices of today. We want to revolutionize the lyophilization process in the same way.”The lyophilization process requires big pieces of equipment that create a low temperature and pressure environment to push water into the vapor phase, so that it leaves the material and collects on condenser coils. Since the equipment is sealed, and it is impossible to check on a process while it is occurring, except through information from one or two sensors. Processing one batch of material can take a few days, which means time is lost if something goes wrong, she said.The conditions required for lyophilization are similar to those in outer space, and the Purdue team plans to apply aerospace engineering principles to the project, Alexeenko said.“Inside the lyophilizer the conditions are a rough vacuum, similar to that at 50 to 100 kilometers altitude in the Earth’s atmosphere, and the fluid dynamics, heat transfer and certain molecular effects are different from what we see under normal conditions,” she said. “Lyophilization is rocket science. We need to approach the equipment design the same way we approach a new spacecraft design, by first understanding in detail all of the forces and mechanics involved and using some of the special physical effects of the rarefied environment to our advantage.”The development of new sensors that are less bulky and better distributed within the system is one approach to help control the processing. Advancing process analytical technologies and sensors for process development, monitoring and control are one of the initial focuses of the consortium, as well as developing standards for lyophilization equipment performance, testing and validation, she said.The consortium brings together industry and academia, representatives from the Food and Drug Administration and other government agencies, equipment manufacturers, and end product users to address the most important problems facing the industry, Topp said.“Consortium members from industry will frame the problems they face, and members from the academic and research side will help work on solutions, while regulators are kept in the loop to ensure  the safety and standards so that changes can be quickly approved,” she said. “We want to entirely rethink and redesign how the processing is done, which will have the ripple effect of improving pharmaceutical manufacturing in general. We can apply what we learn to make other manufacturing processes better, faster and more efficient. This will mean safer and more affordable products.”The leadership team, which in addition to Topp and Alexeenko includes Michael Pikal of the University of Connecticut and Steve Nail of Baxter International Inc., has already created LyoHUB, a website where consortium members can share best practices, new information and projects. LyoHUB also includes computational and process modeling tools to support research.The consortium is currently working to develop a technology roadmap for lyophilization to prioritize research and development projects and goals, and is recruiting members.last_img read more

For Your Voting Pleasure: Ten Startup-Related Panels from the SxSW Panel Picker

first_imgTags:#start Why Tech Companies Need Simpler Terms of Servic… Top Reasons to Go With Managed WordPress Hosting Related Posts A Web Developer’s New Best Friend is the AI Wai…center_img 8 Best WordPress Hosting Solutions on the Market jolie odell When you think about South by Southwest Interactive, your memory may serve up warm recollections of open bars, awesome booth swag, and the occasional keynote worth remembering. But amid the festival atmosphere, thousands of would-be entrepreneurs, web developers, and VCs mill around looking for (or pitching) the Next Big Thing.It comes as no surprise, then, that the SxSW Panel Picker is replete with startup-related panels. Ladies and gentlemen, for your consideration (and votes and comments), here are ten could-be-awesome proposed SxSW panels all about the space we love best. Look closely, and you just might see some themes, such as bootstrapping, revenue models, and life outside the Valley.How Startups Can Create Buzz Without Selling OutOrganizer: David Berkowitz, 360iDavid Berkowitz will lead panelists (whose identities are as yet a mystery) in a discussion about how start-ups can pitch to brands with the credibility, funds, and marketing power to create buzz – and all while retaining their integrity.“Seed Combinators’: Startup Incubators 2.0Organizer: Mark Nathan, Houston Technology CenterBoy, do we love the Y Combinators, SproutBoxes, and TechStars of this world. This panel is all about that unique mashup of seed funding, mentoring, and coworking that is the modern incubator/accelerator for high tech startups.Lessons From the Long Trenches: Bootstrapping 301Organizer: Gareth Knight, TechnovatedBootstrapping is a worthwhile endeavor for many entrepreneurs, but oh, the mistakes you can make. As Mom liked to say, “You don’t have to get hit by a bus to know it hurts.” Attendees of this panel will hear about the obstacles inherent in this process and will hopefully pick up a few practical tips on formulating strategies, finding funds, and managing resources.Startups Without Funding – Forget the VC’s!Organizer: Brad Wayland, BlueCotton.comAlthough the thought of loads of venture capital is intriguing/relieving, this panel contends, “Having your own idea and starting from scratch can be much more rewarding.” By starting small and working smart, entrepreneurs can see a lot more profit and personal benefit in the long run.Creating The Next Hot Startup… For FreeOrganizer: Brian Gorbett, MicrosoftDisclosure: Microsoft BizSpark sponsors this channel. And no, we didn’t get a DM reading, “Vote for my SXSW panel! Thx! Plz RT!!!” Brian Gorbett is a MSFT software architect, and in this solo discussion, he will explore some of the main technology platforms available and share resources and personal experiences that can help startups succeed both from a software architecture perspective and by tapping into a vast network of many tools and services available.Web Startups: Rely On Advertising And You’ll DieOrganizer: Joe Stepniewski, SkimlinksMonetization is a tricky beast, and reliance on advertising as the main source of your site or app’s revenue can be dangerous. So, who’s got a better idea? Vote for this panel, and we all might learn something new and interesting.Cha-Ching!: How to Make Different Revenue Models WorkOrganizer: Brad Jefferson, AnimotoOn a related note, this panel also delves into monetization, allegedly from “a panel of CEOs at booming startups.” Questions for the panel will center around finding the revenue model that best fits your product, vertical, and users.Student Startups: Entrepreneurship in the UniversityOrganizer: Hung Truong, Troubadour MobileMaybe it was something to do with Facebook, but we’ve noticed more and more support for student entrepreneurs, both from educational institutions as well as VCs. This panel of still-wet-behind-the-ears startup wunderkinds will discuss the challenges and benefits of starting early.Coding for Pleasure: Developing Killer Spare-Time AppsOrganizer: Adam Pash, LifehackerAh, the revered spare-time microapp. Is it not every coder’s dream that his side-project web app just might turn into the Next Big Thing? If you’ve ever daydreamed your picture onto the cover of Wired or Fast Company – or if your goals are a bit less lofty, like creating a useful, working application that users enjoy – this is the panel for you.Don’t Move! Build a Startup Community Where You LiveOrganizer: Jeff Slobotski, Silicon Prairie NewsDisclosure: RWW was a media sponsor for BIG Omaha, a Midwest-focused event organized by Slobotski and his Silicon Prairie News cohort, Dusty Davidson. It’s no secret that we at RWW love hearing about startup communities and solo innovators in the Midwest, the Pacific Northeast, and other areas outside the obligatory metropolitan centers. This panel will highlight the startup scenes in Portland, Boulder, Omaha, and New Orleans. This is one panel that definitely gets our vote.You can see all the SxSWi proposed panels here, or just check out the rest of the startup-related ones here.last_img read more

Check Out These 5 Super Simple Tips for Shooting Better Footage

first_imgStruggling to get a better composition? Here are five simple ways you can take your film or video project to the next level.If you’re like me, one of the biggest challenges you’ll face as a filmmaker is making something basic look cinematic. It’s a struggle I face on most shoots, but through trial and error, I’ve developed a  few simple tricks that can make all my coverage look much better in only a few seconds.5 Simple Tips for Better Footage1. Walk around to find the best positionTry filming your subject from a different position. If you’re shooting with the sun, try shooting against it to create depth and atmosphere.2. Zoom-in for a shallow depth of fieldZoom your lens into a tighter focal length, then take a few steps back to compensate for the scaled in frame size. This will create a shallower depth of field. It puts extra focus on your subject, and create a nice soft background. 3. Lower your frame to change perspectivePosition your camera at eye level with your subject. I even like to lower my it so that the camera is against my chest or stomach. This changes the perspective and makes your shots more stable.4. Add subtle movementAdd motion to your footage — I like to apply a subtle move. This can be anything from slightly swaying the camera side-to-side to a smooth sweep around your subject.5. Shoot in slow-motionPut it in slow-motion! Capturing 60fps or more will give you some room to play around when editing. You can simply speed the footage back up if you are working in a 24 or 30fps timeline.last_img read more

ONE: PH’s Corminal wary of ‘new’ Lepont

first_imgLATEST STORIES Stars face off at ONE: Dawn of Heroes PLAY LIST 01:42Stars face off at ONE: Dawn of Heroes02:18Alvarez ready to take risk vs Folayang, looks to end clash by ‘knockout or submission’00:50Trending Articles01:37Protesters burn down Iran consulate in Najaf01:47Panelo casts doubts on Robredo’s drug war ‘discoveries’01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games Stronger peso trims PH debt value to P7.9 trillion Typhoon Kammuri accelerates, gains strength en route to PH Japan ex-PM Nakasone who boosted ties with US dies at 101 Don’t miss out on the latest news and information. Read Next SINGAPORE—Richard Corminal doesn’t think a two-year layoff has made Arnaud Lepont any less dangerous.The Filipino fighter still isn’t taking his French-born foe, who is stepping in the cage for the first time since September 2015, lightly in their upcoming battle in ONE: Immortal Pursuit at Singapore Indoor Stadium here.ADVERTISEMENT QC cops nab robbery gang leader, cohort France’s Arnaud Lepont (L) and Philippines’ Richard Corminal face off during the ONE Championship press conference at Marina Bay in Singapore. INQUIRER PHOTO/ Sherwin VardeleonThis is Corminal’s second fight in the promotion and he has so far been matched up with big names with gaudy resumes in mixed martial arts.It may seem like a daunting task for someone who has only fought professionally six times, but Corminal knows it’s the only way to go up in the sport.“I’m excited. If I managed to sneak a victory, maybe I can improve my name,” said Corminal with a smile.ADVERTISEMENT “I can’t say (I have the advantage) since they said there’s a ‘new version’ of Arnaud Lepont,” said Corminal, who is now based in Malaysia, in Filipino Tuesday after the press conference at Marina Bay Sands. “But I’m ready for whatever happens.”READ: Two Filipino bets complete ONE: Immortal Pursuit FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSSEA Games: Philippines picks up 1st win in men’s water poloSPORTSMalditas save PH from shutoutAside from spoiling Lepont’s return, Corminal also has something to prove after he fell short in his ONE debut last March against top lightweight contender Shannon Wiratchai.“He is a more experienced fighter than I am. I know what he is capable of doing inside the cage,” Corminal said. “I will do my best. I’ve worked hard just to make it here in ONE Championship. I won’t waste this opportunity.” CPP denies ‘Ka Diego’ arrest caused ‘mass panic’ among S. Tagalog NPA MOST READ Kammuri turning to super typhoon less likely but possible — Pagasa ONE: PH’s Corminal wary of ‘new’ Lepont132 viewsSportsVentuno Web Player 4.51 Go easy, Tiger, Day urges ahead of comeback View comments Brace for potentially devastating typhoon approaching PH – NDRRMC Kris Aquino ‘pretty chill about becoming irrelevant’last_img read more

Bradley: Pacquiao still can fight vs young guys

first_imgManny Pacquiao speaks to the media in Brisbane, Tuesday, June 27, 2017. Pacquiao, is putting his WBO belt on the line Sunday, July 2, against the 29-year-old Australian fighter Jeff Horn. (AP Photo/John Pye)BRISBANE, AUSTRALIA—Tim Bradley Jr. has fought Manny Pacquiao three times over 36 rounds in a four-year span.And until now, Bradley still marvels at the way Pacquiao has shown no definite signs of decline as a boxer.ADVERTISEMENT “It’s a little strange, but this guy (Pacquiao) can still fight,” Bradley told Filipino media at the lobby of Sofitel Hotel.“He does well against younger fighters and I think that he will do very well in the fight,” Bradley said, referring to Pacquiao’s defense of the World Boxing Organization welterweight crown on Sunday.FEATURED STORIESSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSPrivate companies step in to help SEA Games hostingSPORTSWin or don’t eat: the Philippines’ poverty-driven, world-beating pool stars“Maybe he wants to show everyone that he still competes at the highest level,” added Bradley, who beat Pacquiao by a controversial split decision in 2012 before losing their rematch in 2014 and trilogy in 2016, is in this Queensland capital to commentate on Pacquiao’s battle with Horn at Suncorp Stadium.After watching Pacquiao’s domination of Jessie Vargas last Nov. 4 in Las Vegas, Bradley is convinced the eight-division world champion has more mileage left in his tank. Cayetano to unmask people behind ‘smear campaign’ vs him, SEA Games Don’t miss out on the latest news and information. LOOK: Jane De Leon meets fellow ‘Darna’ Marian Rivera Another vape smoker nabbed in Lucena MOST READ View comments Lacson: SEA Games fund put in foundation like ‘Napoles case’ What ‘missteps’?center_img Pagasa: Kammuri now a typhoon, may enter PAR by weekend “This guy, he still has the speed, the power, the reflexes to be at the top of boxing,” Bradley noted.Bradley, however, refused to specify the manner (knockout or decision) with which he sees Pacquiao winning.“I don’t know, it’s up to Manny how long he wants it to last,” Bradley said before boarding a waiting cab.ADVERTISEMENT Ceres whips stallion Pagasa: Kammuri now a typhoon, may enter PAR by weekend LATEST STORIES China furious as Trump signs bills in support of Hong Kong Robredo: True leaders perform well despite having ‘uninspiring’ boss PLAY LIST 02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games Sports Related Videospowered by AdSparcRead Nextlast_img read more

Finance Minister Arun Jaitley Leader of Rajya Sabha, Azad Leader of Opposition

first_imgArun Jaitley was named as the Leader of the House in Rajya Sabha on Monday, while Congress veteran Ghulam Nabi Azad was declared the Leader of the Opposition.Rajya Sabha Chairman Hamid Ansari made the announcement.Ansari said Parliamentary Affairs Minister M Venkaiah Naidu had written to him on June 2 informing that Jaitley will the Leader of the House in Rajya Sabha.He said the letter regarding Azad being made the Leader of Congress came to him on Sunday.Jaitley (61), a senior BJP member was earlier Leader of Opposition in the Rajya Sabha during UPA government, while Azad (65) was Union Health Minister.Both Jaitley and Azad lost elections from Amritsar in Punjab and Udhampur in Jammu and Kashmir respectively in this Lok Sabha polls but the tenure of their Rajya Sabha membership still remains.Jaitley had lost to Amarinder Singh of Congress while Azad lost the Lok Sabha polls to BJP’s Jitendra Singh, who is now Minister of State in PMO.While Jaitley is a member of Rajya Sabha from Gujarat, Congress leader Azad is a member from Jammu and Kashmir.-With inputs from PTIlast_img read more

Cheerleaders challenge India’s strictly cricket tradition

first_imgTraditionally, when a batsman hits a six into the crowd, he lifts his bat to acknowledge the applause.But when Delhi Capitals star batsman Rishabh Pant bashes a ball into the stand, he unleashes an explosion of music, smoke and flying pom-poms.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSPalace wants Cayetano’s PHISGOC Foundation probed over corruption chargesSPORTSSingapore latest to raise issue on SEA Games food, logisticsThe dancers who come from Britain, Brazil, Canada, Russia, South Africa and other countries keep grinning and kicking even when temperatures hit 40 degrees Celsius (104 Fahrenheit).When the IPL dancers started in 2008, some politicians wanted them banned because their skimpy outfits were considered un-Indian and Royal Challengers Bangalore now have more soberly dressed, mixed male-female cheerleaders. Private companies step in to help SEA Games hosting Panelo: Duterte ‘angry’ with SEA Games hosting hassles SEA Games hosting troubles anger Duterte Ethel Booba twits Mocha over 2 toilets in one cubicle at SEA Games venue PH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss Image: AFP/Dibyangshu SarkarThey smile and jump in short skirts and tight tops in front of frenzied crowds — but this is cricket. Not a Bollywood set or a Mumbai nightclub.They may not know the rules of Twenty20 cricket, but the cheerleaders who follow the eight Indian Premier League teams have become a key part of the success of the world’s wealthiest cricket tournament that will stage a new final on Sunday.ADVERTISEMENT Steph or Seth? Coin flip to decide who mom, dad represent Philippine Arena Interchange inaugurated Hontiveros presses for security audit of national power grid LATEST STORIEScenter_img “As far as Indian men go, personally it doesn’t bother me. That’s just my mentality, some people I am sure have a different way of thinking. We are here to do a job professionally.”The IPL put up a firewall around players after an illegal gambling scandal in 2013 that saw three players arrested and two teams banned from the league.Even a hint of scandal worries the cricket establishment now.From a distance, the women have to make do with giving nicknames like “Muscle Russell” for West Indies star batsman Andre Russell. And they adore “our number four” Delhi captain Shreyas Iyer.Knowing when to fire up the crowd has been a tough lesson for some, however.“Someone in my podium who was here for the IPL last year knew what to do. Literally, we had no idea about the game until our very first match here,” said Bobi Dorrington from England.“We’d sit there waiting for her to say if it’s a four or a six. We learned as we watched, now we understand the game.” HM/JBRELATED STORIES:Finally, cheerleading is a sportSri Lanka’s Galle cricket stadium faces axe over Dutch fort DA eyes importing ‘galunggong’ anew MOST READ While a metal fence separates the women from fans in stadiums, they still get trolled online. And the sexist jibes from the crowd can be daunting.Charlie Chaeppela said someone created a fake social media account to taunt her.“They used a picture of me while I was cheerleading, they threatened me and asked me why I was in India,” she said.India was thrust into the global spotlight when a 23-year-old woman student was brutally gang-raped and killed in 2012, prompting nationwide protests within the nation.Politicians brought in tougher penalties against sexual offenders and accelerated trials, but campaigners claimed the legislation failed to stem the tide of violence against women.More than 100 rapes a day are reported in India, according to the most recent official government statistics in 2016.But Chaeppela said she still took the job because it was an “incredible opportunity.”“My mom got me a book on India and on the Delhi page, it said it was the worst for women,” Chaeppela said.“But on second thoughts if you look at it, it could happen anywhere in the world.”“I have only done cheerleading in India. The culture, the people, the craziness, it’s so cool,” said Canadian Linda Lopatynski. But there are few complaints now.The troupes follow the teams on a grueling crisscross schedule across India for eight weeks each year. The players get luxury flights and hotels, while the women take the budget version.“There are a lot of rules. Don’t look at them, don’t smile at them,” English cheerleader Kelly Smith said of the dancers’ relations with the players.“We help them win the games in a way, we should be able to meet and interact with them,” added the 24-year-old, one of a dozen women in the Delhi Capitals cheerleaders team.Five days of thisADVERTISEMENT Don’t miss out on the latest news and information. Cayetano: Senate, Drilon to be blamed for SEA Games mess Sports Related Videospowered by AdSparcRead Next View commentslast_img read more

Football Urban Meyers Texas to Ohio recruiting pipeline in 2017

OSU football coach Urban Meyer disputes a call made by the Officials during the game against Michigan on Nov. 26 at Ohio Stadium. The Buckeyes won 30-27. Credit: Mason Swires | Assistant Photo EditorTexas became a popular state for recruiting for Ohio State football coach Urban Meyer this year, with five players making the long journey to Columbus from the Lone Star State. The 2017 recruiting class is a testament to Meyer’s ability to reach far across the nation.This season, Jeffrey Okudah, Baron Browning, J.K. Dobbins, Kendall Sheffield and Elijah Gardiner all came to OSU as part of 21 new players for the Scarlet and Gray.The Texas to Ohio pipeline started for Meyer and company back in 2013, when the newest OSU football players from the state were Dontre Wilson, Mike Mitchell and J.T. Barrett. While all three players were former four-star recruits, each has traveled a much different path in college.Wilson, a once highly touted player who had the speed and hands to play both wide receiver and running back, suffered a foot injury that kept him out of contention for an extended period of time. His career with the Buckeyes is now over, and never really lived up to the hype that surrounded his initial signing.Mitchell never panned out with the Buckeyes, transferring to Texas Tech before winding up with Southeastern University, which is a National Association of Intercollegiate Athletics program. Barrett, who is returning for his redshirt senior season, is poised to break nearly every OSU passing record in the books.In 2014, OSU snagged now-redshirt sophomore guard Demetrius Knox from Texas before no commitments from the state of Texas for the next two years. Then, everything clicked.Meyer’s success in Texas might have been a product of a staff full of quality recruiters as well as the team’s accomplishments. Appearances in the College Football Playoff two out of three years since its inception seems like an enticing factor for any incoming freshman.For Browning, it was all about the opportunities presented by a program like OSU. “I would say probably the reason everyone is leaving Texas is because everybody wanna be great, so they’re going to where they feel like they can grow the most,” he said on National Signing Day.However, Okudah said the tight-knit bond between the group was the key that led to the success in Texas for OSU.“The coaches, they had come out and recruit us, they did a pretty good job,” he said. “They might of got a little bit lucky, because we were all pretty close before so when they got one of us,I would go tell Baron, ‘Did you hear this? Did you hear that?’ and he would say, ‘Yeah.’ It made it easy for us to be comfortable so far from home.”All incoming players from Texas agreed Columbus is a city where they can grow both on and off the field, and where the dreams of winning a national championship and one day playing in the NFL are all very real possibilities. The Texas natives and the rest of the Buckeyes will get a chance to show off their skills on April 15 in the Spring Game. With multiple starting spots open on either side of the ball, any one of the five could find their way into the starting lineup. On top of that, there seemed to be one more thing they all could agree on — a longing for Whataburger.“I haven’t had (Whataburger) in a long time,” Dobbins said “So I’m kind of missing it.” read more